Anti-ABL1 Polyclonal Antibody
品牌：solarbio | 货号：K006660P
| 英文名称 | Anti-ABL1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | ABL;JTK7;p150;c-ABL;v-abl;c-ABL1;bcr/abl |
| 应用 | IHC |
| 稀释比例 | IHC 1:50-200. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 123kDa |
| Gene ID | 25 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human ABL1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human ABL1 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | P00519 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.? |