Anti-SPATA13 Polyclonal Antibody
品牌：solarbio | 货号：K006838P
| 英文名称 | Anti-SPATA13 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | ASEF2;ARHGEF29;RP11-307N16.3 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:200-1000. IHC 1:25-100. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 75kDa |
| Gene ID | 221178 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human SPATA13 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human SPATA13 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q96N96 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. Both the ABR and the SH3 domains contribute to maintaining the protein in an inhibited conformation by associating with the C-terminal tail. Binding of these domains to the C-terminal tail inhibits the activity of the protein by blocking a region that is required for its GEF activity. |