Anti-EID1 Polyclonal Antibody
品牌：solarbio | 货号：K007024P
| 英文名称 | Anti-EID1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CRI1;EID-1;RBP21;PTD014;C15orf3;PNAS-22;IRO45620 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:200-1000. IHC 1:25-100. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 21kDa |
| Gene ID | 23741 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human EID1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human EID1 |
| Subcellular Locations | Nucleus Cytoplasm |
| Swiss Prot | Q9Y6B2 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | E1A-like inhibitor of differentiation-1 (EID-1), an acetyltransferase enzyme, binds both the retinoblastoma protein (Rb), a regulator of cell cycle and tissue specific transcription, and the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EID-1 inhibits cellular differentiation by blocking the histone acetyltransferase activity of p300. EID-1 also acetylates both histones and non-histone proteins such as NCOA3 co-activator. By acetylating histones, EID-1 gives a specific tag for transcriptional activation. In addition to binding Rb and p300, EID-1 also binds to phosphorylated CREB protein, mediating cAMP gene regulation. EID-1 augments the activity of phosphorylated CREB and activates transcription of cAMP responsive genes as a co-activator. |