Anti-TGFB2 Polyclonal Antibody
品牌：solarbio | 货号：K003684P
| 英文名称 | Anti-TGFB2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | G-TSF;LDS4;TGF-beta2 |
| 应用 | WB IF |
| 稀释比例 | WB 1:200-2000. IF 1:50-200. |
| 交叉反应 | Human MouseRat |
| 蛋白分子量 | 48kDa |
| Gene ID | 7042 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant Protein of human TGFB2 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant Protein of human TGFB2 |
| Subcellular Locations | Secreted |
| Swiss Prot | P61812 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters’ anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. |