Anti-RFX5 Polyclonal Antibody
品牌：solarbio | 货号：K004902P
| 英文名称 | Anti-RFX5 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | RFX5 |
| 应用 | WB IF |
| 稀释比例 | WB 1:500-2000. IF 1:50-100. |
| 交叉反应 | Human |
| 蛋白分子量 | 65kDa |
| Gene ID | 5993 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human RFX5 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human RFX5 |
| Subcellular Locations | Nucleus |
| Swiss Prot | P48382 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. |