Anti-MDM2 Polyclonal Antibody
品牌：solarbio | 货号：K106576P
| 英文名称 | Anti-MDM2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | ACTFS;hdm2;HDMX;E3 ubiquitin-protein ligase Mdm2 |
| 应用 | WB |
| 稀释比例 | WB 1:3000. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 48kDa |
| Gene ID | 4193 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human MDM2 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human MDM2 |
| Subcellular Locations | Nucleus |
| Swiss Prot | Q00987 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Inhibits TP53/p53- and TP73/p73-mediated cell cyclearrest and apoptosis by binding its transcriptional activation domain. Functions as a ubiquitin ligase E3, in the presence of E1 and E2, toward p53 and itself. Permits the nuclear export of p53 and targets it for proteasome-mediated proteolysis. Binds p53, p73, ARF(P14), ribosomal protein L5 and specifically to RNA. Can interact also with retinoblastoma protein(RB), E1A-associated protein EP300 and the E2F1 transcription factor. Forms a ternary complex with TP53/p53 and WWOX. |