Myxochelin A

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产品编号 产品名称 产品规格 产品等级 产品价格
AG-CN2-0470-C100 Myxochelin A 100 ug － －
AG-CN2-0470-M001 Myxochelin A 1 mg － －
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Myxochelin AMyxochelin A


　　人强效5-脂氧合酶抑制剂（5-LO），该酶催化花生四烯酸转化成白三烯的前两部，是众所周知的炎症和过敏反应介质。

铁离子螯合物

　　抗癌症抗生素，在体外抑制肿瘤细胞侵袭。

抗菌化合物

　　具有清除自由基活性的抗氧化剂。

参考文献


[1]

Myxochelin A, a new iron-chelating compound from Angiococcus disciformis (Myxobacterales). Production, isolation, physico-chemical and biological properties: B. Kunze, et al.; J. Antibiot. 42, 14 (1989)

[2]

Myxochelin A, a cytotoxic antibiotic from the myxobacterium Angiococcus disciformis: J.W. Ahn, et al.; OPEM 2, 64 (2001)

[3]

Antioxidative and free radical scavenging activities of Myxochelin A isolated from Angiococcus sp.(Myxobacteria): H.-H. Lee, et al.; Food Sci. Biotech. 11, 184 (2002)

[4]

Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861: S. Miyanaga, et al.; J. Antibiot. 59, 698 (2006)

[5]

Synthesis and evaluation of myxochelin analogues as antimetastatic agents: S. Miyanaga, et al.; Bioorg. Med. Chem. 17, 2724 (2009)

[6]

Myxochelins target human 5-lipoxygenase: S. Schieferdecker, et al.; J. Nat. Prod. 78, 335 (2015)

[7]

Harnessing enzymatic promiscuity in Myxochelin biosynthesis for the production of 5-Lipoxygenase inhibitors: J. Korp, et al.; Chembiochem. 16, 2445 (2015)

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