Anti-NSD1 Polyclonal Antibody
品牌：solarbio | 货号：K006143P
| 英文名称 | Anti-NSD1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | ARA267;KMT3B;SOTOS;SOTOS1;STO |
| 应用 | WB |
| 稀释比例 | WB 1:500-1000. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 297kDa |
| Gene ID | 64324 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human NSD1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human NSD1 |
| Subcellular Locations | Chromosome Nucleus |
| Swiss Prot | Q96L73 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene. |