Anti-Kir6.2 Polyclonal Antibody
品牌：solarbio | 货号：K107035P
| 英文名称 | Anti-Kir6.2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | KCNJ11,BIR,HHF2,IKATP,MODY13,PHHI,TNDM3,ATP-sensitive inward rectifier potassium channel 11 |
| 应用 | WB |
| 稀释比例 | WB 1:5000-8000. |
| 交叉反应 | Human |
| 蛋白分子量 | 44/33kDa |
| Gene ID | 3767 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human Kir6.2 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human Kir6.2 |
| Subcellular Locations | Cell membrane |
| Swiss Prot | Q14654 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. |