Anti-DEPTOR Polyclonal Antibody
品牌：solarbio | 货号：K008034P
| 英文名称 | Anti-DEPTOR Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | DEP.6;DEPDC6 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:200-1000. IHC 1:25-100. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 46kDa |
| Gene ID | 64798 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human DEPTOR |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human DEPTOR |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q8TB45 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | DEPTOR (DEP domain containing MTOR-interacting protein), also known as DEP.6 or DEPDC6 (DEP domain-containing protein 6), is a 409 amino acid protein that negatively regulates mTORC1 and mTORC2 pathways. DEPTOR interacts with FRAP via its PDZ domain, and undergoes post-translational phosphorylation. Containing two DEP domains and one PDZ (DHR) domain, DEPTOR is encoded by a gene that maps to human chromosome 8q24.12. Chromosome 8 consists of nearly 146 million base pairs, encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8. |