Anti-PEG10 Polyclonal Antibody
品牌：solarbio | 货号：K003486P
| 英文名称 | Anti-PEG10 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | EDR;HB-1;MEF3L;Mar2;Mart2;RGAG3;RTL2;SIRH1 |
| 应用 | WB |
| 稀释比例 | WB 1:200-2000. |
| 交叉反应 | Human |
| 蛋白分子量 | 80kDa |
| Gene ID | 23089 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human PEG10 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human PEG10 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | Q86TG7 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene. |