Anti-WRN Polyclonal Antibody
品牌：solarbio | 货号：K007975P
| 英文名称 | Anti-WRN Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | RECQ3;RECQL2;RECQL3 |
| 应用 | IHC |
| 稀释比例 | IHC 1:30-150. |
| 交叉反应 | Human |
| 蛋白分子量 | 162kDa |
| Gene ID | 7486 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human WRN |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human WRN |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | Q14191 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3′ to 5′ DNA helicase activity, and is also a 3′ to 5′ exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. |