Anti-WWTR1 Polyclonal Antibody
品牌：solarbio | 货号：K008017P
| 英文名称 | Anti-WWTR1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | TAZ |
| 应用 | WB |
| 稀释比例 | WB 1:200-1000. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 44kDa |
| Gene ID | 25937 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human WWTR1 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human WWTR1 |
| Swiss Prot | Q9GZV5 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The transcriptional co-activator with PDZ-binding motif (TAZ) is a 14-3-3-binding molecule. The highly conserved and ubiquitously expressed 14-3-3 proteins regulate differentiation, cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in signal transduction. TAZ may link events at the plasma membrane and cytosketeton to nuclear transcription in a manner that can be regulated by 14-3-3. TAZ shares homology with the WW domain of Yes-associated protein (YAP) and functions as a transcriptional co-activator by binding to the PPXY motif present on transcription factors. TAZ recognizes immunoreactive protein bands in lysates from MDCK, NIH-3T3 and 293T cells. In addition, COS7, Hep G2, CHO and HeLa cells express endogenous TAZ. 14-3-3 binding requires TAZ phosphorylation on a single Serine 89 residue, resulting in the inhibition of TAZ transcriptional co-activation through 14-3-3-mediated nuclear export. |