Anti-NPHP1 Polyclonal Antibody
品牌：solarbio | 货号：K007338P
| 英文名称 | Anti-NPHP1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | NPH1;JBTS4;SLSN1 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-300. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 83kDa |
| Gene ID | 4867 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human NPHP1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human NPHP1 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | O15259 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a protein with src homology domain 3 (SH3) patterns. This protein interacts with Crk-associated substrate, and it appears to function in the control of cell division, as well as in cell-cell and cell-matrix adhesion signaling, likely as part of a multifunctional complex localized in actin- and microtubule-based structures. Mutations in this gene cause familial juvenile nephronophthisis type 1, a kidney disorder involving both tubules and glomeruli. Defects in this gene are also associated with Senior-Loken syndrome type 1, also referred to as juvenile nephronophthisis with Leber amaurosis, which is characterized by kidney and eye disease, and with Joubert syndrome type 4, which is characterized by cerebellar ataxia, oculomotor apraxia, psychomotor delay and neonatal breathing abnormalities, sometimes including retinal dystrophy and renal disease. Multiple transcript variants encoding different isoforms have been found for this gene. |