Anti-BEST1 Polyclonal Antibody
品牌：solarbio | 货号：K004172P
| 英文名称 | Anti-BEST1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | ARB;BEST;BMD;RP50;TU15B;VMD2 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 68kDa |
| Gene ID | 7439 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human BEST1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human BEST1 |
| Subcellular Locations | Basolateral cell membrane Cell membrane Multi-pass membrane protein |
| Swiss Prot | O76090 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms. |