Anti-MDC1 Polyclonal Antibody
品牌：solarbio | 货号：K005781P
| 英文名称 | Anti-MDC1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | NFBD1 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:100-200. |
| 交叉反应 | Human |
| 蛋白分子量 | 227kDa |
| Gene ID | 9656 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human MDC1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human MDC1 |
| Subcellular Locations | Chromosome Nucleus |
| Swiss Prot | Q14676 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. |