Anti-PRKAA2 Polyclonal Antibody
品牌：solarbio | 货号：K005185P
| 英文名称 | Anti-PRKAA2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | AMPK;AMPK2;AMPKa2;PRKAA |
| 应用 | WB IHC IF |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. IF 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 62kDa |
| Gene ID | 5563 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human PRKAA2 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human PRKAA2 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | P54646 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. |