Anti-DCLK1 Polyclonal Antibody
品牌：solarbio | 货号：K007586P
| 英文名称 | Anti-DCLK1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CL1;DCLK;CLICK1;DCDC3A;DCAMKL1 |
| 应用 | WB |
| 稀释比例 | WB 1:200-1000. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 82kDa |
| Gene ID | 9201 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human DCLK1 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human DCLK1 |
| Swiss Prot | O15075 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities. |