Anti-CCM2 Polyclonal Antibody
品牌:solarbio | 货号:K007292P
英文名称 |
Anti-CCM2 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
OSM;C7orf22;PP10187 |
应用 |
IHC |
稀释比例 |
IHC 1:20-100. |
交叉反应 |
Human |
蛋白分子量 |
49kDa |
Gene ID |
83605 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human CCM2 |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human CCM2 |
Subcellular Locations |
Cytoplasm |
Swiss Prot |
Q9BSQ5 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene. |