Anti-IDO2 Polyclonal Antibody
品牌：solarbio | 货号：K007243P
| 英文名称 | Anti-IDO2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | INDOL1 |
| 应用 | WB |
| 稀释比例 | WB 1:200-1000. |
| 交叉反应 | Human |
| 蛋白分子量 | 45kDa |
| Gene ID | 169355 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Full length fusion protein |
| 性状 | 液体 |
| Public Immunogen Range | Full length fusion protein |
| Subcellular Locations | Cytosol |
| Swiss Prot | Q6ZQW0 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | INDOL1 is also known as IDO2 (indoleamine 2,3-dioxygenase 2) and is a 407 amino acid protein that is expressed in various tissues, including liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, colon and dendritic cells. INDOL1 is selectively inhibited by D-1MT (1-methyl-d-tryptophan), which also inhibits IDO (indoleamine 2,3-dioxygenase) and is significant because IDO expression causes suppression of T cell responses to tumors in dendritic cells. The inhibition of INDOL1 by D-1MT suggests a common function in immunomodulation. In the human INDOL1 gene, two single nucleotide polymorphisms have been detected which abolish the enzymatic function of INDOL1. |