Anti-SMAD4 Polyclonal Antibody
品牌：solarbio | 货号：K004113P
| 英文名称 | Anti-SMAD4 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | DPC4;JIP;MADH4;MYHRS |
| 应用 | WB IF |
| 稀释比例 | WB 1:500-2000. IF 1:50-200. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 60kDa |
| Gene ID | 4089 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human SMAD4 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human SMAD4 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | Q13485 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. |