Anti-RPE65 Polyclonal Antibody
品牌：solarbio | 货号：K006081P
| 英文名称 | Anti-RPE65 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | BCO3;LCA2;RP20;mRPE65;rd12;sRPE65 |
| 应用 | WB |
| 稀释比例 | WB 1:500-2000. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 61kDa |
| Gene ID | 6121 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human RPE65 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human RPE65 |
| Subcellular Locations | Cell membrane Cytoplasm Lipid-anchor Microsome membrane |
| Swiss Prot | Q16518 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. |