Anti-PTPN11 Polyclonal Antibody
品牌：solarbio | 货号：K008230P
| 英文名称 | Anti-PTPN11 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CFC;NS1;SHP2;BPTP3;PTP2C;PTP-1D;SH-PTP2;SH-PTP |
| 应用 | WB IHC |
| 稀释比例 | WB 1:200-1000. IHC 1:25-100. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 68kDa |
| Gene ID | 5781 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human PTPN11 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human PTPN11 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q06124 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. |