Anti-SIRPA Polyclonal Antibody
品牌：solarbio | 货号：K005985P
| 英文名称 | Anti-SIRPA Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | BIT;CD172A;MFR;MYD-1;P84;PTPNS1;SHPS1;SIRP |
| 应用 | WB |
| 稀释比例 | WB 1:500-2000. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 55kDa |
| Gene ID | 140885 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human SIRPA |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human SIRPA |
| Subcellular Locations | Membrane Single-pass type I membrane protein |
| Swiss Prot | P78324 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. |