Hampton GRAS 5 • GRAS 6 Screens

Applications

 GRAS reagent crystallization screen for proteins, including monoclonal antibodies, where Polyethylene glycol is the primary reagent, sampling pH 4.5 to 10

. Identify GRAS based reagents that promote crystallization of biotherapeutics for bioprocess, bioformulation, and continuous flow manufacturing applications

Features

Description

GRAS Screen™ 5 and 6 were developed by Hampton Research for the crystallization of proteins, including monoclonal antibodies. Each of the chemicals in GRAS Screen 5 and 6 has been used under one or more of the following categories. As (1) a Generally Recognized As Safe (GRAS) substance, (2) a pharmaceutical excipient, (3) a normal physiological constituent, (4) a metabolic byproduct, and/or (5) a Everything Added to Food in the United States (EAFUS) substance.

GRAS Screen 5 samples four low molecular weight Polyethylene glycols (300, 400, MME 550, and 600) at three concentrations versus eight unique buffers encompassing pH 4.5 to 10. GRAS Screen 5 is supplied in a 96 Deep Well block format and is compatible with robotic and multi-channel pipet liquid handling systems. GRAS Screen 5 is compatible with vapor diffusion, free interface diffusion, and microbatch crystallization methods. For research use only.

GRAS Screen 6 samples four medium molecular weight Polyethylene glycols (1,000, MME 2,000, 3,350, & 4,000) at three concentrations versus eight unique buffers encompassing pH 4.5 to 10. GRAS Screen 6 is supplied in a 96 Deep Well block format and is compatible with robotic and multi-channel pipet liquid handling systems. GRAS Screen 6 is compatible with vapor diffusion, free interface diffusion, and microbatch crystallization methods. For research use only.

Hampton Optimize Reagents

1、Optimize – Polymers

Crystallization grade polymers for formulating screens or optimization

2、Optimize – Organics (Volatile)

Crystallization grade organics (volatile) for formulating screens or optimization

3、Optimize – Organics (Non-Volatile)

Crystallization grade organics (non-volatile) for formulating screens or optimization

4、Optimize – Salts

Crystallization grade salts for formulating screens or optimization

5、Optimize – Buffers

Crystallization grade buffers for formulating screens or optimization

6、Optimize – Solubilizing Agents (NDSB)

Crystallization grade non detergent sulfobetaines

7、Optimize – Reducing Agent

TCEP Hydrochloride

8、Optimize – Monoolein

LCP – Lipidic Cubic Phase

9、Optimize – Cryoprotectants

For cryoprotection of crystals

10、Optimize – Oils for Crystallization

Microbatch crystallization & oil layering

11、Optimize – Izit Crystal Dye

Izit™ color dye to differentiate protein crystals from salt crystals

Hampton 0.1毫米50号玻璃毛细管

货号：HR6-104
包装：25 pack

• 英文名：0.1 mm Glass Number 50 Capillary
• 品牌：Hampton

Hampton代理–金畔生物

硼硅玻璃50号毛细管壁厚0.01毫米，全长80毫米+ / – 5毫米。提供外径从0.1毫米到2毫米的毛细管，用于X射线数据收集，晶体密度测量和晶体生长实验。毛细管可以用蜡，环氧树脂等密封材料封闭，防止水分和气体。

应用

X射线数据采集

液-液扩散结晶

凝胶针状结晶

特征

50号硼硅玻璃

壁厚 10微米

描述

硼硅玻璃50号毛细管一端呈漏斗形，另一端封闭，壁厚0.01毫米，全长80毫米+/-5毫米，外径从0.1毫米到2毫米。可嵌入，盛放，储存小分子和生物大分子晶体用于X射线数据收集，晶体密度测量和晶体生长实验。毛细管可以用蜡，环氧树脂和其它密封材料密封，防止水分和气体。

请参照“线性吸收系数µcm-1表“，以决定适合的玻璃/石英玻璃毛细管。本表展示的是X射线数据收集时的辐射吸收量。

0.1mm至2.0mm毛细管开口端的基础尺寸为：3.0+/-0.15mm外径 x 0.13+/-0.10 mm壁厚，直径为在毛细管封闭端40毫米处的测量值。

 

货号	产品说明	公差
HR6-104	Size: 0.1 mm – 25 pack	0.1 mm -0.075 / +0.075 mm
HR6-106	Size: 0.2 mm – 25 pack	0.2 mm -0.050 / +0.050 mm
HR6-108	Size: 0.3 mm – 25 pack	0.3 mm -0.050 / +0.100 mm
HR6-110	Size: 0.4 mm – 25 pack	0.4 mm -0.100 / +0.100 mm
HR6-112	Size: 0.5 mm – 25 pack	0.5 mm -0.100 / +0.100 mm
HR6-114	Size: 0.6 mm – 25 pack	0.6 mm -0.100 / +0.100 mm
HR6-116	Size: 0.7 mm – 25 pack	0.7 mm -0.150 / +0.150 mm
HR6-118	Size: 0.8 mm – 25 pack	0.8 mm -0.150 / +0.150 mm
HR6-120	Size: 0.9 mm – 25 pack	0.9 mm -0.150 / +0.150 mm
HR6-122	Size: 1.0 mm – 25 pack	1.0 mm -0.150 / +0.250 mm
HR6-124	Size: 1.5 mm – 25 pack	1.5 mm -0.250 / +0.250 mm
HR6-126	Size: 2.0 mm – 25 pack	2.0 mm -0.250 / +0.250 mm

Hampton蛋白结晶产品目录

Hampton GRAS 3 • GRAS 4 Screens

Applications

a.GRAS reagent crystallization screen for proteins, including monoclonal antibodies, where Salt is the primary, and Polyethylene glycol the secondary reagent, sampling pH 4-9

b.Identify GRAS based reagents that promote crystallization of biotherapeutics for bioprocess, bioformulation, and continuous flow manufacturing applications

Features

 Description
GRAS Screen™ 3 and GRAS Screen™ 4 were developed by Hampton Research for the crystallization of proteins, including monoclonal antibodies. Each of the chemicals in GRAS Screen 3 and 4 have been used under one or more of the following categories. As (1) a Generally Recognized As Safe (GRAS) substance, (2) a pharmaceutical excipient, (3) a normal physiological constituent, (4) a metabolic byproduct, and/or (5) a Everything Added to Food in the United States (EAFUS) substance.

GRAS Screen 3 samples twenty four salts, encompassing pH 4-9 versus four low molecular weight Polyethylene glycols (300, 400, MME 550, & 600). GRAS Screen 3 is supplied in a 96 Deep Well block format and is compatible with robotic and multi-channel pipet liquid handling systems. GRAS Screen 3 is compatible with vapor diffusion, free interface diffusion, and microbatch crystallization methods. For research use only.

GRAS Screen 4 samples twenty four salts, encompassing pH 4-9 versus four medium molecular weight Polyethylene glycols (1,000, MME 2,000, 3,350 & 4,000). GRAS Screen 4 is supplied in a 96 Deep Well block format and is compatible with robotic and multi-channel pipet liquid handling systems. GRAS Screen 4 is compatible with vapor diffusion, free interface diffusion, and microbatch crystallization methods. For research use only.