APRF;HIES;Signal transducer and activator of transcription 3
应用
WB IHC
稀释比例
WB 1:1000-2000. IHC 1:100-200.
交叉反应
Human Mouse Rat
蛋白分子量
79kDa/86kDa
Gene ID
6774
保存
Store at -20°C. Avoid freeze / thaw cycles.
储存液
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法
Affinity purification
亚型
IgG1
免疫原
recombinant protein
性状
液体
Public Immunogen Range
recombinant protein
Subcellular Locations
Cytoplasm Nucleus
Swiss Prot
P40763
克隆号
1.00E+03
克隆类型
Monoclonal Antibody
背景资料
Signal transducer and activator of transcription 3, also known as STAT3, is a transcription factor which in humans is encoded by the STAT3 gene. Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities.
This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19.
