Anti-Phospho-MAPK14-T180/Y182 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-Phospho-MAPK14-T180/Y182 Polyclonal Antibody

品牌:solarbio | 货号:K006211P

英文名称 Anti-Phospho-MAPK14-T180/Y182 Polyclonal Antibody
宿主 Rabbit
别名 CSBP;CSBP1;CSBP2;CSPB1;EXIP;Mxi2;PRKM14;PRKM15;RK;SAPK2A;p38;p38ALPHA
应用 WB IHC
稀释比例 WB 1:500-2000. IHC 1:50-200.
交叉反应 Human Rat
蛋白分子量 41kDa
Gene ID 1432
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A phospho specific peptide corresponding to residues surrounding T180/Y182 of human MAPK14
性状 液体
Public Immunogen Range A phospho specific peptide corresponding to residues surrounding T180/Y182 of human MAPK14
Subcellular Locations Cytoplasm Nucleus
Swiss Prot Q16539
克隆类型 Polyclonal Antibody
背景资料 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

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