Anti-GHRL Polyclonal Antibody
品牌:solarbio | 货号:K007952P
英文名称 |
Anti-GHRL Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
MTLRP |
应用 |
WB |
稀释比例 |
WB 1:200-1000. |
交叉反应 |
Human Mouse Rat |
蛋白分子量 |
13kDa |
Gene ID |
51738 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
A synthetic peptide of human GHRL |
性状 |
液体 |
Public Immunogen Range |
A synthetic peptide of human GHRL |
Swiss Prot |
Q9UBU3 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression. |