Anti-HRAS Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-HRAS Polyclonal Antibody

品牌:solarbio | 货号:K005541P

英文名称 Anti-HRAS Polyclonal Antibody
宿主 Rabbit
别名 C-BAS/HAS;C-H-RAS;C-HA-RAS1;CTLO;H-RASIDX;HAMSV;HRAS1;RASH1;p21ras
应用 WB IHC
稀释比例 WB 1:500-2000. IHC 1:50-200.
交叉反应 Human Mouse Rat
蛋白分子量 21kDa
Gene ID 3265
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human HRAS
性状 液体
Public Immunogen Range A synthetic peptide of human HRAS
Subcellular Locations Cell membrane Cytoplasm Cytoplasmic side Golgi apparatus Golgi apparatus membrane Lipid-anchor Lipid-anchor Nucleus perinuclear region
Swiss Prot P01112
克隆类型 Polyclonal Antibody
背景资料 This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

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